Dataset Information

ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations.

ABSTRACT: ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation-based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built-in PK/PD ordinary differential equations library of models to choose from alongside the ability to plug in a user-defined model from a local or project directory. The user interface consists of several key inputs for performing the simulations as well as options to visualize the plots, perform simple noncompartmental analysis, and review inputs and model code. It also provides the ability to download the underlying model, plots, simulated data, or a comprehensive report consisting of all the key inputs and outputs of the simulations. The interface includes advanced features where users can overlay external data on a simulation, set a certain simulation scenario as a reference, or carry out sensitivity analysis-based simulations. This easy-to-use interface can serve as a valuable tool to project teams to evaluate potential scenarios facilitating collaborative decision making in the drug discovery and development paradigm.

SUBMITTER: Vaddady P

PROVIDER: S-EPMC8592511 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations.

Vaddady Pavan P Kandala Bhargava B

CPT: pharmacometrics & systems pharmacology 20210821 11

ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation-based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built-in PK/PD ordinary differential equations library of models to choose from alongside the ability to plug in a user-defined model from a local or project directory. The user interface consists of several key inputs for performing the simulations as well as options to visualize the plots, perf ...[more]

PMID: 34319009

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Project description:BACKGROUND:Even though R is one of the most commonly used statistical computing environments, it lacks a graphical user interface (GUI) that appeals to students, researchers, lecturers, and practitioners in medicine and pharmacy for conducting standard data analytics. Current GUIs built on top of R, such as EZR and R-Commander, aim to facilitate R coding and visualization, but most of the functionalities are still accessed through a command-line interface (CLI). To assist practitioners of medicine and pharmacy and researchers to run most routines in fundamental statistical analysis, we developed an interactive GUI; i.e., MEPHAS, to support various web-based systems that are accessible from laptops, workstations, or tablets, under Windows, macOS (and IOS), or Linux. In addition to fundamental statistical analysis, advanced statistics such as the extended Cox regression and dimensional analyses including partial least squares regression (PLS-R) and sparse partial least squares regression (SPLS-R), are also available in MEPHAS. RESULTS:MEPHAS is a web-based GUI (https://alain003.phs.osaka-u.ac.jp/mephas/) that is based on a shiny framework. We also created the corresponding R package mephas (https://mephas.github.io/). Thus far, MEPHAS has supported four categories of statistics, including probability, hypothesis testing, regression models, and dimensional analyses. Instructions and help menus were accessible during the entire analytical process via the web-based GUI, particularly advanced dimensional data analysis that required much explanation. The GUI was designed to be intuitive for non-technical users to perform various statistical functions, e.g., managing data, customizing plots, setting parameters, and monitoring real-time results, without any R coding from users. All generated graphs can be saved to local machines, and tables can be downloaded as CSV files. CONCLUSION:MEPHAS is a free and open-source web-interactive GUI that was designed to support statistical data analyses and prediction for medical and pharmaceutical practitioners and researchers. It enables various medical and pharmaceutical statistical analyses through interactive parameter settings and dynamic visualization of the results.

Dataset Information

ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations.

Publications

ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations.

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