COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank.

ABSTRACT:

Background

With the increasing number of people infected with and recovered from coronavirus disease 2019 (COVID-19), the extent of major health consequences of COVID-19 is unclear, including risks of severe secondary infections.

Methods

Based on 445,845 UK Biobank participants registered in England, we conducted a matched cohort study where 5151 individuals with a positive test result or hospitalized with a diagnosis of COVID-19 were included in the exposed group. We then randomly selected up to 10 matched individuals without COVID-19 diagnosis for each exposed individual (n = 51,402). The life-threatening secondary infections were defined as diagnoses of severe secondary infections with high mortality rates (i.e., sepsis, endocarditis, and central nervous system infections

SUBMITTER: Hou C 

PROVIDER: S-EPMC8592806 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature