Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality.

ABSTRACT: Arginine (Arg) and lysine (Lys) moieties of proteins undergo various post-translational modifications (PTM) including enzymatic N^G- and N^ε-methylation and non-enzymatic N^G- and N^ε-glycation. In a large cohort of stable kidney transplant recipients (KTR, n = 686), high plasma and low urinary concentrations of asymmetric dimethylarginine (ADMA), an abundant PTM metabolite of Arg, were associated with cardiovascular and all-cause mortality. Thus, the prediction of the same biomarker regarding mortality may depend on the biological sample. In another large cohort of stable KTR (n = 555), higher plasma concentrations of N^ε-carboxymethyl-lysine (CML) and N^ε-carboxyethyl-lysine (CEL), two advanced glycation end-products (AGEs) of L

SUBMITTER: Baskal S 

PROVIDER: S-EPMC8592953 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature