Early and late stage MPN patients show distinct gene expression profiles in CD34⁺ cells.

ABSTRACT: Myeloproliferative neoplasms (MPN), comprising essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), are hematological disorders of the myeloid lineage characterized by hyperproliferation of mature blood cells. The prediction of the clinical course and progression remains difficult and new therapeutic modalities are required. We conducted a CD34⁺ gene expression study to identify signatures and potential biomarkers in the different MPN subtypes with the aim to improve treatment and prevent the transformation from the rather benign chronic state to a more malignant aggressive state. We report here on a systematic gene expression analysis (GEA) of CD34⁺ peripheral blood or bone marrow cells derived from 30 patients with MPN including a

SUBMITTER: Baumeister J 

PROVIDER: S-EPMC8592960 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature