Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.

ABSTRACT: The widespread incidence of cardiovascular diseases and associated mortality and morbidity, along with the advent of powerful computational resources, have fostered an extensive research in computational modeling of vascular pathophysiology field and promoted in-silico models as a support for biomedical research. Given the multiscale nature of biological systems, the integration of phenomena at different spatial and temporal scales has emerged to be essential in capturing mechanobiological mechanisms underlying vascular adaptation processes. In this regard, agent-based models have demonstrated to successfully embed the systems biology principles and capture the emergent behavior of cellular systems under different pathophysiological conditions. Furthermore, through their modular str

SUBMITTER: Corti A 

PROVIDER: S-EPMC8593007 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature