Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC8593035 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Han Yang Y Hu Xinting X Yun Xiaoya X Liu Jiarui J Yang Juan J Tian Zheng Z Zhang Xin X Zhang Ya Y Wang Xin X
Cell death & disease 20211115 11
Nucleolar and spindle-associated protein 1 (NUSAP1) is an essential regulator of mitotic progression, spindle assembly, and chromosome attachment. Although NUSAP1 acts as an oncogene involved in the progression of several cancers, the exact role of chronic lymphocytic leukemia (CLL) remains elusive. Herein, we first discovered obvious overexpression of NUSAP1 in CLL associated with poor prognosis. Next, the NUSAP1 level was modulated by transfecting CLL cells with lentivirus. Silencing NUSAP1 in ...[more]