Exploring arterial tissue microstructural organization using non-Gaussian diffusion magnetic resonance schemes.

ABSTRACT: The purpose of this study was to characterize the alterations in microstructural organization of arterial tissue using higher-order diffusion magnetic resonance schemes. Three porcine carotid artery models namely; native, collagenase treated and decellularized, were used to estimate the contribution of collagen and smooth muscle cells (SMC) on diffusion signal attenuation using gaussian and non-gaussian schemes. The samples were imaged in a 7 T preclinical scanner. High spatial and angular resolution diffusion weighted images (DWIs) were acquired using two multi-shell (max b-value = 3000 s/mm²) acquisition protocols. The processed DWIs were fitted using monoexponential, stretched-exponential, kurtosis and bi-exponential schemes. Directionally variant and invariant microstructura

SUBMITTER: Shahid SS 

PROVIDER: S-EPMC8593063 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature