Comprehensive study of α-terpineol-loaded oil-in-water (O/W) nanoemulsion: interfacial property, formulation, physical and chemical stability.

ABSTRACT: In this study, the interfacial ability of α-terpineol (α-TOH) was reported, followed by its trapping into oil-in-water (O/W) nanoemulsion as active-ingredient and the long-term observation of this nanosystem influenced by the storage-time (410-days) and temperature (5, 25, 50 °C). The results indicated that the α-TOH can reduce the interfacial tension on the liquid-liquid interface (ΔG°_m = -1.81 KJ mol^-1; surface density = 8.19 × 10^-6mol m^-2; polar head group area = 20.29 Ų), in the absence or presence of surfactant. The O/W nanoemulsion loaded with a high amount of α-TOH (90 mg mL^-1; 9α-TOH-NE) into the oil phase was successfully formulated. Among the physical parameters, the mean droplet diameter (MDD) showed a great the

SUBMITTER: de Oliveira Felipe L 

PROVIDER: S-EPMC8593137 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature