Ontology highlight
ABSTRACT:
SUBMITTER: Chandra S
PROVIDER: S-EPMC8593223 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Chandra Soumyanetra S Chattopadhyay Gopinath G Varadarajan Raghavan R
Frontiers in genetics 20211102
<i>Mycobacterium tuberculosis</i> harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in <i>M. tuberculosis</i> persistence and disease. The MazE antitoxin has a disordered C-terminal domain that binds the toxin, MazF and neutralizes its endoribonuclease activity. However, the structure of most MazEF TA complexes remains unsolved till date, obscuring structural and functional information about the ...[more]