Using Climate-HIV to describe real-world clinical outcomes for people living with HIV taking dolutegravir-based regimens.

ABSTRACT:

Objectives

The objective of this study was to describe the real-world use and effectiveness of dolutegravir-based regimens (DBRs) in routine clinical practice in the United Kingdom.

Methods

Retrospective analysis was conducted using data from four National Health Service trusts using Climate-HIV, an electronic case record system. Eligible patients were aged ≥18 years with HIV-1 infection who were prescribed a DBR from December 2012 to March 2018. Outcome measurements were accessed at DBR initiation and at weeks 24, 48 and 96 and the last recorded visit up to the extraction date (last measurement). The primary endpoint was the proportion of patients with HIV-1 RNA <50 copies/mL at Week 48.

Results

The study cohort included 934 patients; 337 (36%) were female, 414 (47%)

SUBMITTER: Okoli C 

PROVIDER: S-EPMC8593281 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature