Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria.

ABSTRACT:

Purpose

The aim of this case-control study was to determine the impact of environmental factors on the predisposition to develop keratoconus in a sample of Western Algerian population. Subsequently, we were interested in the implication of two single nucleotide polymorphisms (SNPs) IL4 rs2070874 and FOXP3 rs3761548, previously described as contributing to the occurrence of allergy, in the development of keratoconus.

Methods

The study included 70 unrelated KC cases and 70 controls originating from Western Algeria. DNA genotyping was done using predesigned probe-based allelic discrimination TaqManⓇ assays. Allele and genotype frequencies were compared between the cases and controls by Chi-square test and odds ratios with 95% confidence intervals.

Results

A

SUBMITTER: Meteoukki W 

PROVIDER: S-EPMC8593538 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature