Exploring microsatellite instability in patients with advanced hepatocellular carcinoma and its tumor microenvironment.

ABSTRACT:

Background and aim

Immune checkpoint inhibitors and their combination with other agents have recently been available in advanced hepatocellular carcinoma (HCC). Hence, a thorough understanding of the tumor microenvironment based on tumor samples is yet to be achieved. This study aimed to explore the tumor microenvironment in advanced HCC in terms of microsatellite instability-high (MSI-H) by using tumor samples from advanced HCC patients eligible for systemic therapy.

Methods

MSI-H was assessed by polymerase chain reaction, and the expression of mismatch repair proteins, PD-L1, CD8, VEGF, and HLA-class1 was evaluated by immunohistochemistry. Whole-exome sequencing was performed for MSI-H tumor samples.

Results

Of 50 patients, one (2.0%) was confirmed with MSI-H. In th

SUBMITTER: Mukai S 

PROVIDER: S-EPMC8593775 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature