Identifying the link between chemical exposures and breast cancer in African American women via integrated in vitro and exposure biomarker data.

ABSTRACT: Among women, breast cancer is the most prevalent form of cancer worldwide and has the second highest mortality rate of any cancer in the United States. The breast cancer related death rate is 40 % higher in non-Hispanic Black women compared to non-Hispanic White women. The incidence of triple negative breast cancer (TNBC), an aggressive subtype of breast cancer for which there is no targeted therapy, is also approximately three times higher for Black, relative to, White women. The drivers of these differences are poorly understood. Here, we aimed to identify chemical exposures which play a role in breast cancer disparities. Using chemical biomonitoring data from the National Health and Nutrition Examination Survey (NHANES) and biological activity data from the EPA's ToxCast program, we ass

SUBMITTER: Polemi KM 

PROVIDER: S-EPMC8593892 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature