Prodromal frontotemporal dementia: clinical features and predictors of progression.

ABSTRACT:

Background

The prodromal phase of frontotemporal dementia (FTD) is still not well characterized, and conversion rates to dementia and predictors of progression at 1-year follow-up are currently unknown.

Methods

In this retrospective study, disease severity was assessed using the global CDR plus NACC FTLD. Prodromal FTD was defined to reflect mild cognitive or behavioural impairment with relatively preserved functional independence (global CDR plus NACC = 0.5) as well as mild, moderate and severe dementia (classified as global CDR plus NACC = 1, 2, 3, respectively). Disease progression at 1-year follow-up and serum NfL measurements were acquired in a subgroup of patients.

Results

Of 563 participants, 138 were classified as prodromal FTD, 130 as mild, 175 as moderate an

SUBMITTER: Benussi A 

PROVIDER: S-EPMC8594126 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature