Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage.

ABSTRACT:

Background

Alzheimer's disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Presenilin1 represses cell proliferation by inhibiting the Wnt/β-catenin pathway in glioblastoma. However, the function of Presenilin1 and the underlying mechanism need to be further investigated.

Methods

The correlations of two genes were conducted on the R2 microarray platform and CGGA. Wound healing, Transwell assays and glioblastoma transplantation were performed to detect invasion ability. Phalloidin staining was employed to show cell morphology. Proximity ligation assays and protein docking assays were employed to detect two protein locations. We also empl

SUBMITTER: Yang W 

PROVIDER: S-EPMC8594175 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature