Low cerebrospinal fluid Amyloid-βeta 1-42 in patients with tuberculous meningitis.

ABSTRACT:

Background

Tuberculous meningitis (TBM) is an important disease leading to morbidity, disability and mortality that primarily affects children and immune-depressed patients. Specific neuromarkers predicting outcomes, severity and inflammatory response are still lacking. In recent years an increasing number of evidences show a possible role for infective agents in developing neurodegenerative diseases.

Methods

We retrospectively included 13 HIV-negative patients presenting with TBM and we compared them with two control groups: one of patients with a confirmed diagnosis of AD, and one of those with syphilis where lumbar punctures excluded central nervous system involvement. Lumbar punctures were performed for clinical reasons and CSF biomarkers were routinely available: we ana

SUBMITTER: Stroffolini G 

PROVIDER: S-EPMC8594191 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature