Prediction of anti-CD25 and 5-FU treatments efficacy for pancreatic cancer using a mathematical model.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with rising incidence and with 5-years overall survival of less than 8%. PDAC creates an immune-suppressive tumor microenvironment to escape immune-mediated eradication. Regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSC) are critical components of the immune-suppressive tumor microenvironment. Shifting from tumor escape or tolerance to elimination is the major challenge in the treatment of PDAC.

Results

In a mathematical model, we combine distinct treatment modalities for PDAC, including 5-FU chemotherapy and anti- CD25 immunotherapy to improve clinical outcome and therapeutic efficacy. To address and optimize 5-FU and anti- CD25 treatment (to suppress MDSCs and Tregs, respective

SUBMITTER: Shafiekhani S 

PROVIDER: S-EPMC8594222 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature