Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.

ABSTRACT: Cross-sectional studies in adults have long identified differences in cortical structure in adults with depression compared to healthy adults, with most studies identifying reductions in grey matter volume, cortical thickness, and surface area in primarily frontal cortical regions including the OFC, ACC, and variable sub-regions of the PFC. However, when, why, and for whom these neural correlates of depression emerge remains poorly understood, necessitating developmental study of associations between depression and cortical structure. We systematically reviewed studies examining these associations in child/adolescent samples, and applied a developmentally-focused diathesis-stress model to understand the impacts of depressogenic risk-factors and stressors on the development of structural ne

SUBMITTER: Nielsen JD 

PROVIDER: S-EPMC8594424 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature