Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that develops due to the interaction between genetic and environmental factors. More than 160 loci have been associated with IBD, but the functional implication of many of the associated genes remains unclear. N6-Methyladenosine (m6A) is the most abundant internal modification in mRNA. m6A methylation regulates many aspects of mRNA metabolism, playing important roles in the development of several pathologies. Interestingly, SNPs located near or within m6A motifs have been proposed as possible contributors to disease pathogenesis. We hypothesized that certain IBD-associated SNPs could regulate the function of genes involved in IBD development via m6A-dependent mechanisms. We used online availa

SUBMITTER: Sebastian-delaCruz M 

PROVIDER: S-EPMC8594712 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature