A Newly Defined Pyroptosis-Related Gene Signature for the Prognosis of Bladder Cancer.

ABSTRACT:

Background

Bladder cancer (BC), as the most common urinary system tumor type and the main cause of tumor-related death, has an unsatisfactory prognosis. In recent years, related literature has proposed that cell pyroptosis is an inflammatory form of programmed cell death. However, in BC, the relationship between the expression of pyroptosis-related genes and the prognosis has not been elucidated.

Methods

We got the RNA sequencing data from TCGA and GEO datasets. Fifty-two pyroptosis-related genes were extracted for further explore. Then, we compared the gene expression levels between the normal bladder and BC tissues. After that, we develop and validate a pyroptosis-related gene prognostic model and made following functional enrichment analysis and single-sample gene set enr

SUBMITTER: Chen W 

PROVIDER: S-EPMC8594790 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature