Ontology highlight
ABSTRACT:
SUBMITTER: Howe LJ
PROVIDER: S-EPMC8594845 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Howe Laurence J LJ Battram Thomas T Morris Tim T TT Hartwig Fernando P FP Hemani Gibran G Davies Neil M NM Smith George Davey GD
PLoS genetics 20211104 11
Spousal comparisons have been proposed as a design that can both reduce confounding and estimate effects of the shared adulthood environment. However, assortative mating, the process by which individuals select phenotypically (dis)similar mates, could distort associations when comparing spouses. We evaluated the use of spousal comparisons, as in the within-spouse pair (WSP) model, for aetiological research such as genetic association studies. We demonstrated that the WSP model can reduce confoun ...[more]