Clinical trial representativeness and treatment intensity in a real-world sample of women with early stage breast cancer.

ABSTRACT:

Purpose

The extent to which evidence-based treatments are applied to populations not well represented in early stage breast cancer (EBC) trials remains unknown. This study evaluated treatment intensity for patients traditionally well represented, underrepresented, and unrepresented in clinical trials.

Methods

This retrospective cohort study used real-world data to evaluate the intensity (high or low) of EBC chemotherapy by patient characteristics (age, race and ethnicity, presence of comorbidity) denoting clinical trial representation status (well represented, underrepresented, unrepresented) for patients diagnosed from 2011 to 2020. Odds ratios (OR) from a logistic regression model was used to evaluate the association between receipt of high-intensity chemotherapy and clini

SUBMITTER: Rocque GB 

PROVIDER: S-EPMC8594932 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature