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Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.

ABSTRACT: Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy.

SUBMITTER: Shapiro LC 

PROVIDER: S-EPMC8595142 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy. ...[more]

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