Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
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ABSTRACT:
SUBMITTER: Shapiro LC
PROVIDER: S-EPMC8595142 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
Shapiro Lauren C LC Thakkar Astha A Campbell Sean T ST Forest Stefanie K SK Pradhan Kith K Gonzalez-Lugo Jesus D JD Quinn Ryann R Bhagat Tushar D TD Choudhary Gaurav S GS McCort Margaret M Sica R Alejandro RA Goldfinger Mendel M Goel Swati S Anampa Jesus D JD Levitz David D Fromowitz Ariel A Shah Akash Pradip AP Sklow Charlotte C Alfieri Gregory G Racine Andrew A Wolgast Lucia L Greenberger Lee L Verma Amit A Halmos Balazs B
Cancer cell 20211116 1
Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy. ...[more]
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