Intestinal CD11b⁺ B Cells Ameliorate Colitis by Secreting Immunoglobulin A.

ABSTRACT: The intestinal mucosal immune environment requires multiple immune cells to maintain homeostasis. Although intestinal B cells are among the most important immune cells, little is known about the mechanism that they employ to regulate immune homeostasis. In this study, we found that CD11b⁺ B cells significantly accumulated in the gut lamina propria and Peyer's patches in dextran sulfate sodium-induced colitis mouse models and patients with ulcerative colitis. Adoptive transfer of CD11b⁺ B cells, but not CD11b^-/- B cells, effectively ameliorated colitis and exhibited therapeutic effects. Furthermore, CD11b⁺ B cells were found to produce higher levels of IgA than CD11b^- B cells. CD11b deficiency in B cells dampened IgA production, resulti

SUBMITTER: Fu Y 

PROVIDER: S-EPMC8595478 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature