Opportunistic application of phantom-less calibration methods for fracture risk prediction using QCT/FEA.

ABSTRACT:

Objectives

Quantitative computed tomography (QCT)-based finite element analysis (FEA) implements a calibration phantom to estimate bone mineral density (BMD) and assign material properties to the models. The objectives of this study were to (1) propose robust phantom-less calibration methods, using subject-specific tissues, to obtain vertebral fracture properties estimations using QCT/FEA; and (2) correlate QCT/FEA predictions to DXA values of areal BMD.

Methods

Eighty of a cohort of 111 clinical QCT scans were used to obtain subject-specific parameters using a phantom calibration approach and for the development of the phantom-less calibration equations. Equations were developed based on the HU measured from various soft tissues and regions, and using multiple linear regres

SUBMITTER: Prado M 

PROVIDER: S-EPMC8595493 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature