Thyroarytenoid Muscle Gene Expression in a Rat Model of Early-Onset Parkinson's Disease.

ABSTRACT:

Objectives/hypothesis

Voice disorders in Parkinson's disease (PD) are early-onset, manifest in the preclinical stages of the disease, and negatively impact quality of life. The complete loss of function in the PTEN-induced kinase 1 gene (Pink1) causes a genetic form of early-onset, autosomal recessive PD. Modeled after the human inherited mutation, the Pink1-/- rat demonstrates significant cranial sensorimotor dysfunction including declines in ultrasonic vocalizations. However, the underlying genetics of the vocal fold thyroarytenoid (TA) muscle that may contribute to vocal deficits has not been studied. The aim of this study was to identify differentially expressed genes in the TA muscle of 8-month-old male Pink1-/- rats compared to wildtype controls.

Study design

Animal ex

SUBMITTER: Lechner SA 

PROVIDER: S-EPMC8595495 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature