Gray and White Matter Correlates of Dysphagia in Progressive Supranuclear Palsy.

ABSTRACT:

Background

Dysphagia is a common symptom of progressive supranuclear palsy often leading to aspiration pneumonia and death.

Objective

The aim of this study was to examine how impairments of the oral and pharyngeal phases of the swallow and airway incursion during liquid swallows relate to gray and white matter integrity.

Methods

Thirty-eight participants with progressive supranuclear palsy underwent videofluorographic swallowing assessment and structural and diffusion tensor head magnetic resonance imaging. Penalized linear regression models assessed relationships between swallowing metrics and regional gray matter volumes and white matter fractional anisotropy and mean diffusivity.

Results

Oral phase impairments were associated with reduced superior parietal v

SUBMITTER: Clark HM 

PROVIDER: S-EPMC8595517 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature