Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4^-/-/Bco2^-/- double knockout mice.

ABSTRACT: Accumulation of bisretinoids such as A2E and its isomer iso-A2E is thought to mediate blue light-induced oxidative damage associated with age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1). We hypothesize that increasing dietary intake of the macular carotenoids lutein and zeaxanthin in individuals at risk of AMD and STGD1 can inhibit the formation of bisretinoids A2E and iso-A2E, which can potentially ameliorate macular degenerative diseases. To study the beneficial effect of macular carotenoids in a retinal degenerative diseases model, we used ATP-binding cassette, sub-family A member 4 (Abca4^-/-)/β,β-carotene-9',10'-oxygenase 2 (Bco2^-/-) double knockout (KO) mice that accumulate elevated levels of A2E and iso-A2E in the retinal

SUBMITTER: Arunkumar R 

PROVIDER: S-EPMC8595537 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature