Ontology highlight
ABSTRACT:
SUBMITTER: Rothlauf PW
PROVIDER: S-EPMC8595544 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Rothlauf Paul W PW Li Zeyang Z Pishesha Novalia N Xie Yushu Joy YJ Woodham Andrew W AW Bousbaine Djenet D Kolifrath Stephen C SC Verschoor Vincent L VL Ploegh Hidde L HL
Frontiers in immunology 20211103
Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that enables tracking of immune cells in living animals. We used a nanobody that recognizes mouse CD8α and labeled it with <sup>89</sup>Zr to image mouse CD8<sup>+</sup> T cells in the course of an infection with influenza A virus (IAV). The CD8<sup>+</sup> signal showed a strong increase in the mediastinal lymph node (MLN) and thymus as early as 4 days post-infection (dpi), and as early as 6 dpi in the lungs. Over ...[more]