Cognitive impairment burden in older and younger adults across the kidney transplant care continuum.

ABSTRACT:

Background

Younger kidney transplant (KT) candidates and recipients may have cognitive impairment due to chronic diseases and reliance on dialysis.

Methods

To quantify cognitive impairment burden by age across the KT care continuum, we leveraged a two-center cohort study of 3854 KT candidates at evaluation, 1114 recipients at admission, and 405 recipients at 1-year post-KT with measured global cognitive performance (3MS) or executive function (Trail Making Test). We also estimated burden of severe cognitive impairment that affects functional dependence (activities of daily living [ADL] < 6 or instrumental activities of daily living [IADL] < 8).

Results

Among KT candidates, global cognitive impairment (18-34 years: 11.1%; 35-49 years: 14.0%; 50-64 years: 19.5%; ≥65 yea

SUBMITTER: Chu NM 

PROVIDER: S-EPMC8595550 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature