Hyperpolarization of common antifungal agents with SABRE.

ABSTRACT: Signal amplification by reversible exchange (SABRE) is a robust and inexpensive hyperpolarization (HP) technique to enhance nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) signals using parahydrogen (pH₂ ). The substrate scope of SABRE is continually expanding. Here, we present the polarization of three antifungal drugs (voriconazole, clotrimazole, and fluconazole) and elicit the detailed HP mechanisms for ¹ H and ¹⁵ N nuclei. In this exploratory work, ¹⁵ N polarization values of ~1% were achieved using 50% pH₂ in solution of 3-mM catalyst and 60-mM substrate in perdeuterated methanol. All hyperpolarized ¹⁵ N sites exhibited long T₁ in excess of 1 min at a clinically relevant fie

SUBMITTER: MacCulloch K 

PROVIDER: S-EPMC8595556 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature