International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

ABSTRACT:

Background

Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated.

Objective

Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging.

Methods

Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score.

Resu

SUBMITTER: Laansma MA 

PROVIDER: S-EPMC8595579 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature