Dataset Information

International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

ABSTRACT:

Background

Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated.

Objective

Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging.

Methods

Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score.

Results

Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (d_max = -0.20, d_min = -0.09). The bilateral putamen (d_left = -0.14, d_right = -0.14) and left amygdala (d = -0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures.

Conclusions

Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

SUBMITTER: Laansma MA

PROVIDER: S-EPMC8595579 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

Laansma Max A MA Bright Joanna K JK Al-Bachari Sarah S Anderson Tim J TJ Ard Tyler T Assogna Francesca F Baquero Katherine A KA Berendse Henk W HW Blair Jamie J Cendes Fernando F Dalrymple-Alford John C JC de Bie Rob M A RMA Debove Ines I Dirkx Michiel F MF Druzgal Jason J Emsley Hedley C A HCA Garraux Gäetan G Guimarães Rachel P RP Gutman Boris A BA Helmich Rick C RC Klein Johannes C JC Mackay Clare E CE McMillan Corey T CT Melzer Tracy R TR Parkes Laura M LM Piras Fabrizio F Pitcher Toni L TL Poston Kathleen L KL Rango Mario M Ribeiro Letícia F LF Rocha Cristiane S CS Rummel Christian C Santos Lucas S R LSR Schmidt Reinhold R Schwingenschuh Petra P Spalletta Gianfranco G Squarcina Letizia L van den Heuvel Odile A OA Vriend Chris C Wang Jiun-Jie JJ Weintraub Daniel D Wiest Roland R Yasuda Clarissa L CL Jahanshad Neda N Thompson Paul M PM van der Werf Ysbrand D YD

Movement disorders : official journal of the Movement Disorder Society 20210720 11

<h4>Background</h4>Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated.<h4>Objective</h4>Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging.<h4>Methods</h4>Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional ...[more]

PMID: 34288137

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Dataset Information

International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

Background

Objective

Methods

Results

Conclusions

Publications

International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

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