A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

ABSTRACT:

Background

Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, or system level, that are elicited in response to stressors. We describe the PRIME-KNEE study as an example of ongoing research to validate provocative clinical tests and biomarkers that predict resilience to specific health stressors.

Methods

PRIME-KNEE is an ongoing, prospective cohort study that will enroll 250 adults ≥60 years undergoing total knee arthroplasty. Data are collected at baseline (pre-surgery), during surgery, daily for 7 days after surgery, and at 1, 2, 4, and 6 months post-surgery. Provocative tests includ

SUBMITTER: Whitson HE 

PROVIDER: S-EPMC8595699 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature