Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension.

ABSTRACT:

Background

Autophagy, a highly conserved homeostatic mechanism, is essential for cell survival. The decline of autophagy function has been implicated in various diseases as well as aging. Although mitochondria play a key role in the autophagy process, whether mitochondrial-derived peptides are involved in this process has not been explored.

Methods

We developed a high through put screening method to identify potential autophagy inducers among mitochondrial-derived peptides. We used three different cell lines, mice, c.elegans, and a human cohort to validate the observation.

Results

Humanin, a mitochondrial-derived peptide, increases autophagy and maintains autophagy flux in several cell types. Humanin administration increases the expression of autophagy-related genes a

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC8595716 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature