Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury.

ABSTRACT:

Purpose of review

To report progress in neuromodulation following spinal cord injury (SCI) using combined brain and spinal neuromodulation.Neuromodulation refers to alterations in neuronal activity for therapeutic purposes. Beneficial effects are established in disease states such as Parkinson's Disease (PD), chronic pain, epilepsy, and SCI. The repertoire of neuromodulation and bioelectric medicine is rapidly expanding. After SCI, cohort studies have reported the benefits of epidural stimulation (ES) combined with training. Recently, we have explored combining ES with deep brain stimulation (DBS) to increase activation of descending motor systems to address limitations of ES in severe SCI. In this review, we describe the types of applied neuromodulation that could be combined in S

SUBMITTER: Noga BR 

PROVIDER: S-EPMC8595808 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature