IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.

ABSTRACT:

Purpose

The survival of women with brain metastases (BM) from breast cancer remains very poor, with over 80% dying within a year of their diagnosis. Here, we define the function of IL13Rα2 in outgrowth of breast cancer brain metastases (BCBM) in vitro and in vivo, and postulate IL13Rα2 as a suitable therapeutic target for BM.

Experimental design

We performed IHC staining of IL13Rα2 in BCBM to define its prognostic value. Using inducible shRNAs in TNBC and HER2⁺ breast-brain metastatic models, we assessed IL13Rα2 function in vitro and in vivo. We performed RNAseq and functional studies to define the molecular mechanisms underlying IL13Rα2 function in BCBM.

Results

High IL13Rα2 expression in BCBM predicted worse survival after BM d

SUBMITTER: Marquez-Ortiz RA 

PROVIDER: S-EPMC8595859 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature