Quantitative lung perfusion blood volume using dual energy CT-based effective atomic number (Zeff ) imaging.

ABSTRACT: Iodine material images (aka iodine basis images) generated from dual energy computed tomography (DECT) have been used to assess potential perfusion defects in the pulmonary parenchyma. However, iodine material images do not provide the needed absolute quantification of the pulmonary blood pool, as materials with effective atomic numbers (Zeff ) different from those of basis materials may also contribute to iodine material images, thus confounding the quantification of perfusion defects. (i) To demonstrate the limitations of iodine material images in pulmonary perfusion defect quantification and (ii) to develop and validate a new quantitative biomarker using effective atomic numbers derived from DECT images. The quantitative relationship between the perfusion blood volume (PBV) in pulmonary

SUBMITTER: Li K 

PROVIDER: S-EPMC8595877 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature