Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review.

ABSTRACT:

Background

Available data show that COVID-19 vaccines may be less effective in immunocompromised populations, who are at increased risk of severe COVID-19.

Objectives

We conducted a systematic review of literature to assess immunogenicity, efficacy and effectiveness of COVID-19 vaccines in immunocompromised populations.

Data sources

We searched Medline and Embase databases.

Study eligibility criteria, patients, interventions

We included studies of COVID-19 vaccines after complete vaccination in immunocompromised patients until 31 August 2021. Studies with <10 patients, safety data only and case series of breakthrough infections were excluded.

Methods

Risk of bias was assessed via the tool developed by the National Institutes of Health on interventional a

SUBMITTER: Galmiche S 

PROVIDER: S-EPMC8595936 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature