Prognostic factors associated with COVID-19 related severity in sickle cell disease.

ABSTRACT:

Background

Equipoise exists regarding sickle cell disease (SCD) as a risk factor for COVID-19 disease severity and variables that increase risk of COVID-19 severity in SCD. Given our health system's large SCD patient catchment, we analyzed our own experience in this regard.

Study methods

Retrospective analysis of the clinical course and factors associated with need for hospitalization and ICU admission of SCD patients diagnosed with COVID-19 through the Northwell Health system from March 1 to Dec 31, 2020.

Results

Of 1098 patients with SCD, 3.3% were diagnosed with COVID-19. Overall rates of hospitalization, ICU admission, cohort mortality, and in-hospital mortality were 80%, 19%, 2.5%,and 3.1%, respectively. By multivariable analysis, hospitalization risk was decreas

SUBMITTER: Yurtsever N 

PROVIDER: S-EPMC8595967 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature