A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment.

ABSTRACT:

Introduction

White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose-specific energy deficit and improves cognitive outcomes in mild cognitive impairment (MCI). How an additional supply of ketones affects glucose or ketone uptake in specific WM fascicles in MCI has not previously been reported.

Methods

This 6-month interventional study included MCI participants randomized to a placebo (n = 16) or ketogenic medium chain triglyceride (kMCT; n = 17) drink. A neurocognitive battery and brain imaging were performed pre- and post-intervention. WM fascicle uptake of ketone and glucose and structural properties were assessed using positro

SUBMITTER: Roy M 

PROVIDER: S-EPMC8596139 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature