Hazards of diisobutyl phthalate (DIBP) exposure: A systematic review of animal toxicology studies.

ABSTRACT:

Background

Biomonitoring studies indicate a trend towards increased human exposure to diisobutyl phthalate (DIBP), a replacement for dibutyl phthalate (DBP). Recent reviews have found DIBP to be a male reproductive toxicant, but have not evaluated other hazards of DIBP exposure.

Objective

To inform chemical risk assessment, we performed a systematic review to identify and characterize outcomes within six broad hazard categories (male reproductive, female reproductive, developmental, liver, kidney, and cancer) following exposure of nonhuman mammalian animals to DIBP or the primary metabolite, monoisobutyl phthalate (MIBP).

Methods

A literature search was conducted in four online scientific databases [PubMed, Web of Science, Toxline, and Toxic Substances Control Act Tes

SUBMITTER: Yost EE 

PROVIDER: S-EPMC8596331 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature