A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.

ABSTRACT:

Introduction

Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder.

Methods

A cohort study with 6-year follow-up including 377 older (≥60 years) outpatients with a DSM-IV-defined depressive disorder and 132 never-depressed controls. Site visits at baseline, 2 and 6-year follow-up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41-item FI was operationalised and validated against the 6-year morali

SUBMITTER: Oude Voshaar RC 

PROVIDER: S-EPMC8596411 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature