Early childhood neurodevelopmental outcome after open prenatal spina bifida aperta repair.

ABSTRACT:

Aim

To investigate neurodevelopmental outcome of children with open prenatal spina bifida aperta (SBA) repair.

Method

Prenatal SBA repair was performed in 130 fetuses at the Zurich Center between 2010 and 2019. Seventy-seven children underwent 1 year assessment with the Griffiths Mental Developmental Scales (Griffiths) and 65 with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) at 2 years. Anatomical and functional level and ambulation status were assessed. Descriptive statistics and multiple linear regression analyses for risk factors were performed.

Results

The Bayley-III cognition composite score in children with prenatal SBA repair was within normal limits but lower compared to population norms (mean=95.15, SD=14.683 vs norm=100, SD

SUBMITTER: Hepp ZS 

PROVIDER: S-EPMC8596420 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature