In vivo macromolecule signals in rat brain ¹ H-MR spectra at 9.4T: Parametrization, spline baseline estimation, and T₂ relaxation times.

ABSTRACT:

Purpose

Reliable detection and fitting of macromolecules (MM) are crucial for accurate quantification of brain short-echo time (TE) ¹ H-MR spectra. An experimentally acquired single MM spectrum is commonly used. Higher spectral resolution at ultra-high field (UHF) led to increased interest in using a parametrized MM spectrum together with flexible spline baselines to address unpredicted spectroscopic components. Herein, we aimed to: (1) implement an advanced methodological approach for post-processing, fitting, and parametrization of 9.4T rat brain MM spectra; (2) assess the concomitant impact of the LCModel baseline and MM model (ie, single vs parametrized); and (3) estimate the apparent T₂ relaxation times for seven MM components.

Methods

A single inv

SUBMITTER: Simicic D 

PROVIDER: S-EPMC8596437 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature