Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children.

ABSTRACT:

Background

Hazelnut allergy, which is characterized by symptoms that range from mild to severe, is one of the most common allergies in children throughout Europe, and an accurate diagnosis of this allergy is therefore essential. However, lipophilic allergens, such as oleosins, are generally underrepresented in diagnostic tests. We therefore sought to characterize the IgE reactivity of raw and roasted hazelnut oleosins, using the sera of hazelnut-allergic pediatric patients.

Methods

Raw and roasted hazelnut oil body-associated proteins were analyzed by means of 1D and 2D electrophoresis and MS. Oleosin IgE reactivity was assessed by immunoblotting with the sera of 27 children who have confirmed hazelnut allergies and from 10 tolerant subjects. A molecular characterization of

SUBMITTER: Nebbia S 

PROVIDER: S-EPMC8596585 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature