Unconventional animal models for traumatic brain injury and chronic traumatic encephalopathy.

ABSTRACT: Traumatic brain injury (TBI) is one of the main causes of death worldwide. It is a complex injury that influences cellular physiology, causes neuronal cell death, and affects molecular pathways in the brain. This in turn can result in sensory, motor, and behavioral alterations that deeply impact the quality of life. Repetitive mild TBI can progress into chronic traumatic encephalopathy (CTE), a neurodegenerative condition linked to severe behavioral changes. While current animal models of TBI and CTE such as rodents, are useful to explore affected pathways, clinical findings therein have rarely translated into clinical applications, possibly because of the many morphofunctional differences between the model animals and humans. It is therefore important to complement these studies with alte

SUBMITTER: Ackermans NL 

PROVIDER: S-EPMC8596618 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature