Elucidating the role of protein synthesis in hippocampus-dependent memory consolidation across the day and night.

ABSTRACT: It is widely acknowledged that de novo protein synthesis is crucial for the formation and consolidation of long-term memories. While the basal activity of many signaling cascades that modulate protein synthesis fluctuates in a circadian fashion, it is unclear whether the temporal dynamics of protein synthesis-dependent memory consolidation vary depending on the time of day. More specifically, it is unclear whether protein synthesis inhibition affects hippocampus-dependent memory consolidation in rodents differentially across the day (i.e., the inactive phase with an abundance of sleep) and night (i.e., the active phase with little sleep). To address this question, male and female C57Bl6/J mice were trained in a contextual fear conditioning task at the beginning or the end of the light phas

SUBMITTER: Raven F 

PROVIDER: S-EPMC8596627 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature