T cell composition and polygenic multiple sclerosis risk: A population-based study in children.

ABSTRACT:

Background and purpose

Patients with multiple sclerosis (MS) have altered T cell function and composition. Common genetic risk variants for MS affect proteins that function in the immune system. It is currently unclear to what extent T cell composition is affected by genetic risk factors for MS, and how this may precede a possible disease onset. Here, we aim to assess whether an MS polygenic risk score (PRS) is associated with an altered T cell composition in a large cohort of children from the general population.

Methods

We included genotyped participants from the population-based Generation R study in whom immunophenotyping of blood T cells was performed at the age of 6 years. Analyses of variance were used to determine the impact of MS-PRSs on total T cell numbers (n = 12

SUBMITTER: de Mol CL 

PROVIDER: S-EPMC8596816 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature