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Decarboxylative Hydroxylation of Benzoic Acids.

ABSTRACT: Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.

SUBMITTER: Su W

PROVIDER: S-EPMC8596882 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Decarboxylative Hydroxylation of Benzoic Acids.

Su Wanqi W Xu Peng P Ritter Tobias T

Angewandte Chemie (International ed. in English) 20211004 45

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications. ...[more]

PMID: 34464007

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