The protein-protein interaction ontology: for better representing and capturing the biological context of protein interaction.

ABSTRACT:

Background

With the rapid increase in the amount of Protein-Protein Interaction (PPI) data, the establishment of an event-centered PPI ontology that contains temporal and spatial vocabularies is urgently needed to clarify PPI biological annotations. In this paper, we propose a precisely designed schema - PPIO (PPI Ontology) for representing the biological context of PPIs.

Results

Inspired by the event model and the distinct characteristics of PPI events, PPIO consists of six core aspects of the information required for reporting a PPI event, including the interactor (who), the biological process (when), the subcellular location (where), the interaction type (how), the biological function (what) and the detection method (which). PPIO is implemented through the integration of

SUBMITTER: Li M 

PROVIDER: S-EPMC8596923 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature